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pentobarbital will reduce the extent or effect of suvorexant by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Watch. Solid CYP3A4 inducers may perhaps reduce suvorexant efficacy; if enhanced suvorexant dose demanded, don't exceed 20 mg/daypentobarbital will minimize the level or result of apremilast by affecting hepatic/intes